8/19/2023 0 Comments Omeros corporation newsOne of these novel targets, GPR174, modulates a new cancer immunity axis recently discovered by Omeros, and the company is advancing GPR174-targeting antibodies and small-molecule inhibitors. Omeros’ pipeline holds a diverse group of preclinical programs including a proprietary-asset-enabled antibody-generating technology and a proprietary GPCR platform through which it controls 54 GPCR drug targets and their corresponding compounds. OMS906, Omeros’ inhibitor of MASP-3, the key activator of the alternative pathway of complement, is in a Phase 1 clinical trial, and the company’s PDE7 inhibitor program OMS527, targeting addiction and movement disorders, has successfully completed a Phase 1 trial. Additional narsoplimab programs are focused on other complement-mediated disorders, including IgA nephropathy, atypical hemolytic uremic syndrome and COVID-19. Omeros’ lead MASP-2 inhibitor narsoplimab targets the lectin pathway of complement, and Omeros is seeking FDA approval of narsoplimab for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Its commercial product OMIDRIA ® (phenylephrine and ketorolac intraocular solution) 1%/0.3% continues to gain market share in cataract surgery. Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, immunologic diseases (e.g., complement-mediated diseases and cancers) and central nervous system disorders. To access the live or subsequently archived webcast of the conference call on the internet, go to the company’s website at. A telephone replay will be available for one week following the call and may be accessed by dialing (855) 859-2056 from the United States and Canada or (404) 537-3406 internationally. To access the live conference call via phone, please dial (844) 831-4029 from the United States and Canada or (920) 663-6278 internationally. Omeros’ management will host a conference call to discuss today’s announcement. It has Breakthrough Therapy and Orphan designations in both HSCT-TMA and IgA nephropathy. Narsoplimab is the first drug candidate submitted to FDA for approval in HSCT-TMA. Omeros plans to request a Type A meeting as soon as possible with FDA to discuss the CRL and determine the most expeditious path forward for the approval of narsoplimab in the treatment of HSCT-TMA. The company worked closely with FDA on the clinical development plan, including with respect to both the single-arm trial to support approval and the definition of response as the primary endpoint. Omeros remains confident in the efficacy and safety data for narsoplimab in HSCT-TMA. There were no chemistry, manufacturing and controls (CMC), safety, or non-clinical issues precluding approval raised in the CRL. In the CRL, FDA expressed difficulty in estimating the treatment effect of narsoplimab in HSCT-TMA and asserted that additional information will be needed to support regulatory approval. HSCT-TMA increases that complexity and worsens outcomes. Food and Drug Administration (FDA) regarding its Biologics License Application (BLA) for narsoplimab in the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA).įollowing HSCT, patients generally have complex clinical courses and are often severely ill. SEATTLE-( BUSINESS WIRE)-Omeros Corporation (Nasdaq: OMER) today announced that the company received a Complete Response Letter (CRL) from the U.S.
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The higher the interest rate, the more your monthly payments will be, and vice versa. Interest rate: Your mortgage's interest rate is the amount your mortgage lender charges you for borrowing the money to purchase your home. The calculator uses a 30-year term as the default. Shorter-term loans come with higher monthly payments and lower overall interest costs. Longer-term loans have lower monthly payments, but you'll pay more total interest. Length of the loan: The amount of time it takes to pay off your mortgage, known as the loan term, will have a big impact on cost and affordability. The calculator's default is 20%, which is the amount you'll need to put down if you want to avoid paying for private mortgage insurance. They can be as low as 3%, depending on the loan type and your credit score. It will likely be more than your total loan amount, which will exclude the money you pay upfront toward the purchase.ĭown payment: Most mortgages require buyers to make a down payment. The purchase price of the home: This is the amount you agree to pay the seller. To estimate your mortgage payment with our calculator, here's what you'll need to provide: Paying an additional $500 each month would reduce the loan length by 146 months.Lowering the interest rate by 1% would save you $51,562.03.Paying a 25% higher down payment would save you $8,916.08 on interest charges. 8/19/2023 0 Comments Meta zooChoose where you play wisely, because your surroundings dictate how powerful your cards are! Cast Water Spells when it's raining to increase their effectiveness and partner Dark Beasties during nighttime to augment their power. Get your own MetaZoo products from Jerseys own family ran card shop and Official MetaZoo Partner Theme decks, Spellbooks, Booster Boxes, Blister Packs. As of January this year, MetaZoo’s newest. The official first set, Cryptid Nation, launched July 2021. MetaZoo™ is a Collectible Card Game with groundbreaking mechanics that break the 4th Wall. MetaZoo was created in August 2020 with a Kickstarter campaign that fundraised 18,249. the Great Veil has now shattered under even more mysterious circumstances.and now the Beasties, Spells, and Artifacts that exist in our world but were once hidden are now yours to control!ĭo you have what it takes to become a Master Caster? Although the brand is new to the TCG scene, the concept is similar to the popular Pokemon cards. This is why magic and the work of miracles disappeared from our collective folklores and became the subject of myths and legends. Product Details Set Checklist Shop Boxes Product Details User Rating: Rating: 0.0 Rate This Product 2021 Topps MetaZoo Cryptid Nation Series 0 puts the focus on the trading card game (TCG) that first debuted in March of 2021. I would say welcome to the world of MetaZoo, but MetaZoo is our world! Magic was hidden away behind a Great Veil put in place by mysterious characters over 1000 years ago.
8/19/2023 0 Comments Best ways to clean trax wood vinylCoreTec also recommends a cleaning product called Encore Care for Luxury Vinyl Flooring. You put the substance, also known as isopropyl alcohol, directly on the stain and rub it with a clean cloth. If you need to deal with a problematic spill or stain, you can use rubbing alcohol. You need to make sure that you rinse with clean water afterward to remove any soap residue.ĬoreTec suggests that floor owners avoid abrasive cleaners, strong detergents, or spray cleaners since these can leave a dull residue behind. You can use warm water and light detergent, such as dish soap, to remove stains from juice or other substances that could leave a sticky residue. You do not want to scrub the liquid because this may rub it further into the flooring. If you leave a spill for too long, it may soak into the flooring or get between the cracks in the planks.įor liquid spills, you can use a cloth or paper towel to soak up the liquid with a blotting motion. It is vital to deal with spills and marks quickly. How to Handle Stains and Spills on your CoreTec Floor? You can institute a no-shoe policy at home and request that visitors also remove their shoes. Shoes with marking soles can leave marks on the floor that can be difficult to remove. You should also keep shoes off your CoreTec flooring. There are also other scratch-protection products on the market if you do not want to use adhesive padding. These products make it possible to slide furniture without scratching. These pads are felt or felt-like composites. You can get non-abrasive adhesive pads to stick to the bottom of the furniture legs. When performing this type of cleaning, you do not want the sofa, tables, and chairs to scratch your floor as you move them. You should occasionally sweep, vacuum, and mop under furniture. How to Avoid Scratches on your CoreTec Flooring You also need to ventilate the room by opening windows or running exhaust fans. You usually need to stay off the floor for one day after the polish application. You then apply two or more coats, as directed by the manufacturer. CoreTec recommends polishing once per year in high traffic areas if needed.īefore polishing, you need to make sure the surface is as clean as possible. Other parts of the room may remain shiny, but you should use polish on the entire room so that it has a uniform color and shine. The surface of CoreTec flooring will eventually lose its shine in areas that see a lot of foot traffic. You can polish your CoreTec floor using at least two coats of a floor polishing product. Steam mops can heat the adhesive that holds the planks in place. You should also avoid using vacuums that have a wet-cleaning feature, and you should never use steam cleaners when cleaning a CoreTec floor. You can use a standard vacuum as long as the wheels do not damage the surface of your flooring. You can find a product that is pH neutral, and then dilute it in water using the ratio recommended by the manufacturer.ĬoreTec advises against using vacuums that have rotating bearing bars because these may scratch the floor. You should also opt for a gentle floor cleaning liquid that does not have an overpowering scent or coloring. You can choose a mop with microfiber, which will provide a gentler clean. CoreTec floors are durable, but you can scratch them if you use an abrasive mop. You will want to find a mop that does not cause scratches on the floor. Sweeping every few days can be helpful, but for deeper clean, you need to mop your CoreTec floor. What Do I Need to Know about Mopping my CoreTech Flooring? You will need to clean a permanent pad after use. You can use either a mop with a disposable pad or one with a built-in pad. You sweep the entire floor and pick up the particles and dirt that you collect with a dustpan. You can perform this kind of dry cleaning with a broom. This routine maintenance cleaning will keep particles from getting ground into the floor, and it can extend the amount of time between wet cleanings. That said, you should maintain the surface by removing dirt and dust regularly. CoreTec floors are vinyl, so they are relatively durable and easy to clean 8/19/2023 0 Comments Time clock app for small businessLets you add shifts in bulk, accommodate multiple shifts in a day, add absences, notes, and reminders.Connectteam also has the provision for visual flags based on what you wish to track such as auto-calculated breaks, overtime, absences and bulk-shifts.GPS locating based on the job, client and number of staff released.It lets you collaborate with employees who are always on the move The time clock feature tracks work hours on internal jobs and external projects.Connecteam is supported on both iOS and Android. This reinforces secure access and makes it easier for your staff to punch in and out. What’s more, the on-site kiosk station within time tracking lets the team log in and log out from one centralized hub using personalized pin codes. Why is Connectteam unique? The setup and implementation are easy, and the interface is simple to navigate. Only 6 years in, their client base includes EY, Sodexo and American Eagle Outfitters. The platform comprises employee communication, time clock, digital forms and checklists, employee training and scheduling. It was founded in 2014 and is based out of New York. Free employee time clock apps 2.1 Connectteam Connectteam is an all-in-one employee management solution. The software includes clocks, selfie-check ins and website blockers to deter employees from wasting time on websites and applications deemed irrelevant to the work they are doing.īest Timesheet App for real-time team collaboration and communication.īest Timesheet App for simple and user-friendly time trackingīest Timesheet App for invoicing and billing features.īest Timesheet App for project management and team collaboration.īest Timesheet App for attendance management and team collaboration.īest Timesheet App for simple and intuitive time tracking.īest Timesheet App for free time trackingīest Timesheet App for employee monitoring and screenshot capture features.Ģ. While such devices can’t be actively used by remote offices, they rely more on time tracking and timesheeting applications. Such tools scan fingerprints and faces to determine that the person checking in is a confirmed employee signing in within the work hours he, or she is contracted for. These tools match employee records against digital signatures and entries to maintain attendance and punch lists.īiometric devices are usually mounted on walls or doors at an office. Some ways to keep track of employee hours include digital attendance systems, employee monitoring software, timesheeting and time tracking software and biometric clock ins. Keeping track of everyone’s hours,(including paid and permitted overtime) ensures that your budget doesn’t stretch into an overhead. How do I keep track of my employee hours?Įmployee hours have a direct correlation with labor costs to the company. How do I keep track of my employee hoursġ. "To explore various kinds of remote team management software that can serve as catalysts to boost organizational efficiency at the workplace, read our informative article that covers it all here." This post, however, is intended to reveal the best timesheet apps for small businesses. I had previously written about construction timesheet apps. Without a timesheet app, you’re continuing to pay for unproductivity. Overlooking the high costs of stolen time eats into your budget. Statistic Brain estimates that employee time theft costs businesses $50 billion every year. What’s even more alarming is an American Payroll Association study that states that time theft can cost businesses up to 7% of their total payroll annually. Time theft costs employers in the U.S alone $400 billion in lost productivity. No matter how tightly-knit your team is, you’ll struggle with information regarding their effort hours during the work window if they’re entering it on spreadsheet trackers. You’re going to need something a little more sophisticated, and this is where the best timesheet apps for small businesses come into play. When you’re a small business, you’re still figuring out processes and relying on a team that is growing at-scale. 8/19/2023 0 Comments Ford edge 2020 cargo coverThe four-cylinder’s 23 mpg combined fuel economy is underwhelming, but still better than the Passport and even with the Murano. This is a pleasant and confident experience if not too exciting. FordĪpart from the ST, the Edge isn’t much about performance, but it isn’t slow or sloppy to drive. It’s not bad overall, but it isn’t cheap and it feels dated compared to newer rivals. Now in its final year, the second-generation Ford Edge hasn’t really changed much since its 2016 introduction. The Blazer is the dynamic hero of this group and the Sorento the nicest overall, but the Edge comes out ahead of others like the Nissan Murano. Three-rowers like the Explorer and Honda Pilot are up to a foot longer overall. The Edge gets cross-shopped against slightly larger three-row crossovers and SUVs, but its 189-inch length falls just 2.3 inches short of the Blazer and Passport. The closest analogs are similar, two-row SUVs, including the Chevrolet Blazer, Honda Passport, Hyundai Santa Fe and Kia Sorento. While a classic in-betweener, the Edge competes with more than a dozen different crossovers. There are many more compacts and three-rows, but not so many small midsize two-row offerings. Predictably, the ST’s performance is reflected at the pump, earning 21 mpg combined to the regular Edge’s 23. This is unremarkable, but not bad by class standards. Most are powered by a 250 horsepower turbocharged four-cylinder mated to an eight-speed automatic transmission, but the ST (“Sports Tuned”) gets a twin-turbo, 335-horsepower 2.7-liter V6 and a seven-speed automatic. There are five trims: SE, SEL, ST-Line, Titanium and the sporty ST. The 2023 model builds on 2019’s refresh with minor tweaks. This SUV falls into the gap between brand’s compact models like the Escape and proper midsize three-rows like the Explorer, and even against some newer competitors, it’s still pretty capable, with standard all-wheel drive (AWD), plenty of room and decent gas mileage. But while the U.S.-market Edge might be in its final days and looking past its peak, it’s still got plenty to offer for some buyers. In China, a new Edge has already debuted but, unlike the related 2024 Lincoln Nautilus, it won’t be coming here. The 2023 Ford Edge will be the last of its kind, at least in America. 8/19/2023 0 Comments Zoom keybase app kept images fromYuan disclosed today (May 7) that his company was buying Keybase, a small New York-based startup that provides encrypted messaging, file-sharing and. Once we have assessed this feedback for integration into a final design, we will announce our engineering milestones and goals for deploying to Zoom users," Yuan wrote. In a surprise announcement, Zoom CEO Eric S. "We will then host discussion sections with civil society, cryptographic experts, and customers to share more details and solicit feedback. The company also plans to publish its encryption designs on May 22, and ask for feedback from other experts. In the blog post, Yuan said the company plans to offer an end-to-end encrypted meeting mode to all paid participants. On April 22, the company released a new version of the app with a higher level of encryption. Zoom has made it a goal to build end-to-end encryption into its video conferencing product after coming under fire in April for falsely marketing their calls as already having that layer of security. Keybase's experienced team will be a critical part of this mission," Yuan said in a blog post. "Our goal is to provide the most privacy possible for every use case, while also balancing the needs of our users and our commitment to preventing harmful behavior on our platform. Additionally, leaders from Zoom and Keybase will work together to figure out what the future looks like for Keybase's product. Keybase allows access from VPNs, over TOR, and from Russian & Nigerian IPs. Keybase comes with everything you need to manage your identity, create secure chats, and share files privately. (Note: Nigeria actually is a huge source of spam and fake accounts on the Internet.) Some spam is coming from the US and Western Europe, but mostly not. zoom (Corey) is now on Keybase, an open source app for encryption and cryptography. May 07, 2020, 01:15 PM EDT Zoom, which has seen a surge in demand for its offering, as well as an uptick in security issues, will now work with Keybase to build end-to-end encryption into its. To be clear, the current spam volume isnt dire, YET. They will proactively identify, address, and enhance the security and privacy capabilities of its platform, Zoom said in a press release. Our next app release will be early next week. Keybase engineers will join Zoom's security engineering unit. The acquisition is part of Zoom's 90-day plan to shore up its privacy and security announced in early April, after the company faced a cavalcade of privacy and security issues amid its huge surge in usage due to the coronavirus pandemic. Keybase has 25 employees, according to CNBC. Keybase's last valuation was $42.6 million after raising a $10.8 million funding round led by Andreessen Horowitz in 2015, according to Pitchbook. Keybase cofounder Max Krohn will now lead Zoom's security engineering team and report directly to Zoom CEO Eric Yuan. Zoom is acquiring Keybase, a secure messaging and file sharing service, as the video communications company tries to improve the privacy and security of its platform. In its earlier days, it had an issue of security but nowadays it has acquired Keybase which provide End-to-End. I love this app and I’m a little sad that the dev team was picked up my Zoom, but I hope this product continues to become better and better.Account icon An icon in the shape of a person's head and shoulders. It is the most popular video conferencing app. End-to-end encryption is used to securely encrypt data so that other than the sender and receiver, no one can decrypt and read it. This will enable Zoom to build end-to-end encryption that can reach current Zoom scalability. The Security Ledger reports ( ) that a flaw in Zoom’s Keybase ( secure chat application left copies of images contained in secure communications on Keybase users’ computers after they were. The only app i feel even completes close to this space is Status Encrypted Messenger, but it has high hurdles because of ultra-anonymous nature and account seeds being improperly stored/lost. Zoom announced its acquisition of Keybase and stated that it’s integrating the latter’s team. Let’s see what keybase does amazingly:Ģ) Requires no identifying information to create a profileĥ) BONUS: built-in crypto wallet to as a nice replacement for venmo/zelle and introduction to crypto for newbies!Ħ) other neat features: cloud storage up to 250gb, git repos, big teams (slack-like messenger for FREE), bot integrations, the list goes on.ġ) sluggish, but i assume it’s because of the encryption/decryption stepsĢ) race for good usernames and cannot change usernames afterwards As millions of isolated people have flocked to Zoom to connect with socially distanced family, friends, and coworkers, the company has faced criticism for. The Security Ledger Exclusive: Flaws in Zoom’s Keybase App Kept Chat Images From Being Deleted. I have been looking for an encrypted and easy-to-use messenger as a longtime disappointed user of iMessages/Signal/WhatsApp. The amount of acquisition remains undisclosed as well. 8/18/2023 0 Comments Giant rider waite tarotThere are plenty of them around, but right now there are a lot of the older editions along with a lot of the newer ones on the market, so as Rainbow says, you really have to ask to be sure. I am sure there are exceptions (Albano Waite), but usually I find I like these best. I have found, as a general rule, that US Games decks printed in Switzerland or Belgium have the best overall quality. Games come to their senses and at least remove the "original and only authorized Waite tarot deck" advertisement from the boxes, as these decks may be authorized, but aren't original anymore.īy the way, the deck I've got was printed in Italy and it has a ISBN nº 0-88079-474-7.ĭon't feel bad atlantean. The seven of swords, for instance, has a huge whitish mark in the middle of the card, crossing it sideways. Besides the plastic feel, the printing itself seems to be of very bad quality, also with missplaced colours and serious printing defects. I was planning to buy their standard and original RWS also, but this new digitalized printing method put me off completely. it seems the font change was nothing compared to what the people at U.S. So I just received a Giant Rider-Waite and well folks. I thought the change in the font type was disrespectfull, as the fonts are actually part of the original design, but as I wanted to have this deck again I decided to give it a try. Then I've learned about the new printing method and the change in the fonts. See our full return policy for details.įor more information see FAQs, Terms & Conditions, Delivery & Shipping, or Contact Us.Many years ago I used to own one standard US Games RWS (1980-84 print) and recently decided to buy a RWS again. Most items can be returned or exchanged within 30 days of delivery. Contact us for a quote if required - delivery dates are NOT guaranteed. We do not normally offer express shipping for international orders. For faster shipping and pre-set charges, you may want to set up a US address with a freight forwarding company which also gives you free shipping from us if your order is $75 or more. Your country may charge import duties, taxes, or fees before delivery - contact your local customs office for information. Import taxes are NOT charged by our cart. Transit time will vary depending on customs & exact destination and we cannot guarantee delivery date. We ship from the US - add 10-15+ days to average delivery for most countries. Overnight delivery is available in some cases but require a special shipping quote. If you require express delivery, you can contact us to verify it is available for that item. Items which are Made to Order or that require freight truck delivery are not, for example. Not all items are available for express delivery. If you must have an item by a specific date, let us know in cart comments during checkout. This is the estimated time for delivery within the USA and is subject to availability, seasonal sales volume, and other unforeseen delays. Out of stock items will automatically ship when available unless canceled by you. We will notify you of any out of stock items as soon as possible or you can contact us in advance to verify availability. Not all manufacturers provide inventory data and even in stock items can be sold out without notice. Items out of stock are indicated above with estimated time of arrival (ETA) when known. Product Code: US-GR78 | Approximate Size (Inches): 2.00 wide x 4.00 deep x 6.50 high | 8/18/2023 0 Comments Image upscaler freeFor example, if the original PNG had dimensions of 640×400 and the upscale ratio is 150%, then the new PNG will have dimensions of 960×600px. You can also immediately verify the result in the output field, which also prints the new dimensions of the updated PNG. If you want to get sharper pixels or if you're working with pixel art, you can disable this option. When an image is upscaled, its pixels are duplicated and an additional "Smooth Upscale" option lets you control the sharpness of the output PNG. Similarly, a 180% zoom parameter will upscale a PNG by 1.8 times and a 650% zoom will upscale the PNG by 6.5 times. To make the image two times larger, you can set the scale to 200% (because 200% is 2×100%). The input PNG always has 100%, which is equal to its original size. The scaling option is specified as a percentage. In this utility, you don't have to specify the new width and height values but instead, you just need to specify the enlargement ratio (how many times the new PNG will be bigger than the existing one). It scales all the pixels in a PNG simultaneously while maintaining the aspect ratio between PNG's width and height. Free Image Upscaler Instant Photo Enhancer Powered by AI Free Image Upscaler 133 Reviews Automatically enhance JPG/PNG photo resolution, remove blur and noise, and enlarge images without losing quality at once. It features an easy-to-use user interface, multiple upscaling options, and the ability to customize output image type ( JPG, PNG, WebP) and location. This browser-based utility upscales PNG images. The best place to start if you’re looking for a free upscaler for single or batch jobs, Upscayl is a free and open source image upscaler that runs locally on your Windows, Mac or Linux machine. 8/18/2023 0 Comments Cartoon ghost of christmas pastIt will tell you, for instance, how to describe something that was about to happen to you in the past before you avoided it by time-jumping forward two days in order to avoid it. Dan Streetmentioner's Time Traveler's Handbook of 1001 Tense Formations. The major problem is simply one of grammar, and the main work to consult in this matter is Dr. All the important changes have happened before the things they were supposed to change and it all sorts itself out in the end. There is no problem with changing the course of history-the course of history does not change because it all fits together like a jigsaw. There is no problem in becoming your own father or mother that a broad-minded and well-adjusted family can't cope with. One of the major problems encountered in time travel is not that of becoming your own father or mother. But needlessly complicated auxiliary verb structures is part of the joke.įrom "The Restaurant at the End of the Universe": Of course, "had been going to happen" is probably just as good, since the future time reference indicated by will/would seems redundant with the "going to". Oh, I might have had "had", but no-one else seems to believe in the subjunctive any more.ĭecember 21, 8:23 is subjunctive (or a modal preterite, if you like), that's why it's "would" and not "will". Quite right about the weak grammar, but the ghost's disclosure works perfectly well. You can see this with the "seems" test: "he seems disappointed with his life". "Disappointed" here is an adjectival passive, not a true passive. Source: Language The Ghost of Christmas Future Imperfect The Ghost of Christmas Future Imperfect.Filed by Mark Liberman under Linguistics in the comics.Update - elevated from Ben Zimmer's contribution in the comments: The spirit is willing, though the grammar is weak …įritz notes that this Stack Exchange post from last year treads a similar path, with a cartoon version here:Īnd he also points us to December 2005 Savage Chickens cartoon that features the "Ghost of Christmas Future Perfect Passive": Fritz Ruehr sent a cartoon that he found this morning on reddit: |
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